In the ARC above the median eminence, neurons expressing neuropeptide Y (NPY) and agouti gene-related protein (AgRP) stimulate food intake and are found medially, while pro-opiomelanocortin (POMC) (precursor of α-melanocyte-stimulating hormone; α-MSH) and cocaine- and amphetamine-regulated transcript (CART) induce anorexia and are coexpressed in the neuronal population of lateral ARC. The gene discussed is POMC; the disease is Anorexia.