Thus, it was found that loss of TPCs can lead to or accelerate the development of hypercholesterolemia and fatty liver hepatitis under certain dietary conditions (Grimm et al., 2014), can slow-down intracellular virus and bacterial toxin trafficking (Ruas et al., 2010, 2014; Sakurai et al., 2015), can affect VEGF-induced neoangiogenesis (Favia et al., 2014), autophagy (Lu et al., 2013a,b; Fernández et al., 2016), and human hair pigmentation (Sulem et al., 2008; Ambrosio et al., 2016; Bellono et al., 2016), and the acrosome reaction in sperm (Arndt et al., 2014). This evidence concerns the gene VEGFA and familial hypercholesterolemia.