There were several limitations to our study that should not be ignored: (1) a small number of participants (43 AD patients, 45 VaD patients and 45 normal subjects) were recruited; (2) genetic factors, such as the CST3 and APOA1–2 genotypes, and anti-lipemic administration were not considered in this study; and (3) to validate and complete the questionnaire, we chose only AD and VaD patients with sufficient cognitive ability, which significantly narrowed the study population. This evidence concerns the gene CST3 and Alzheimer disease.