APOA1 and Alzheimer disease: There were several limitations to our study that should not be ignored: (1) a small number of participants (43 AD patients, 45 VaD patients and 45 normal subjects) were recruited; (2) genetic factors, such as the CST3 and APOA1–2 genotypes, and anti-lipemic administration were not considered in this study; and (3) to validate and complete the questionnaire, we chose only AD and VaD patients with sufficient cognitive ability, which significantly narrowed the study population.