A previous study following patients with mild cognitive impairment (MCI) for 2 years, found that the baseline cerebrospinal fluid (CSF) levels of amyloid-beta 1-43 (Aβ43) could distinguish patients that converted to AD dementia from those that did not, suggesting that CSF Aβ43 could be a useful addition to the more well-studied CSF biomarkers amyloid beta 1-42 (Aβ42), total tau (t-tau), and tau phosphorylated on position 181 (p-tau) (Kandimalla et al., 2011, 2013; Lauridsen et al., 2016). This evidence concerns the gene MAPT and Cognitive impairment.