In this regard, binge-like alcohol exposure increases the nuclear factor-kappa β (NF-κβ)-DNA binding activity, up-regulates the expression of cyclooxygenase-2 (COX-2), causes microglia activation (Knapp and Crews, 1999; Obernier et al., 2002a; Crews et al., 2006) and induces brain injury in the cortex and hippocampus associated with cognitive deficits (Crews et al., 2000; Obernier et al., 2002b; Tajuddin et al., 2014; Antón et al., 2016). This evidence concerns the gene PTGS2 and Cognitive impairment.