Several evidence indicates that alcohol induces the TLR4 signaling in the PFC (Vetreno and Crews, 2012; Pascual et al., 2014), triggering the induction of a cascade of pro-inflammatory mediators that affect, among others, cognitive impairments and anxiety-like behaviors associated with the alcohol abuse (Montesinos et al., 2015; Pascual et al., 2015). This evidence concerns the gene TLR4 and alcohol abuse.