ADAM10 and Alzheimer disease: However, Epis et al. (2010) demonstrated that hippocampal ADAM10/SAP97 levels (a complex required for synaptic ADAM10 localization) are reduced in AD patients, while activity-attenuating mutations in the prodomain of the human ADAM10 gene have been associated with AD (Kim et al., 2009; Suh et al., 2013).