RPPH1 and Seizure: Rpph1 has also been used to as an internal control for RNA quantification (Raoul et al., 2005; Page et al., 2011; Soler-Alfonso et al., 2014) However, recent deep sequencing studies showed that Rpph1 was up-regulated in the human gastric cancer tissues (Xia et al., 2014) and in the neocortex of seizure patients (Lipovich et al., 2012), as well as in cortical samples from the APPswe/PS1ΔE9 mice.