INS and Alzheimer disease: In total, 1082 mRNA targets were inputted into DAVID for KEGG pathway analysis, and 173 of them were enriched in the top eight AD-related pathways as following: adherent junction, insulin signaling pathway, focal adhesion, neurotrophin signaling pathway, MAPK signaling pathway, regulation of actin cytoskeleton (FDR < 0.05, p < 0.05), ErbB signaling pathway, and long-term potentiation and axon guidance (p < 0.05).