PRNP and Parkinson disease: Toxic PrP species (Kristiansen et al., 2005), disease causing PrP mutants (Cohen and Taraboulos, 2003; Mishra et al., 2003), and Parkinson's disease-associated, aggregated α-synuclein (Tanaka et al., 2004; Wong et al., 2008) were also shown to be deposited in aggresomes of mammalian cells, further linking these sites with a myriad of human neurodegenerative illnesses.