Alzheimer's disease (AD), the most common type of dementia, is characterized by two pathological hallmarks; the deposition of small hydrophobic peptides known as β amyloid (Aβ) in plaques and the formation of Neurofibrillary Tangles (NFTs) of aggregated, hyper-phosphorylated microtubule-associated protein tau in the brain (Selkoe, 2011). Here, MAPT is linked to Alzheimer disease.