The levels of CNX and CRT were found to be reduced in Parkinson's disease cellular model (Kuang et al., 2014) and ER stress response was found to be activated in amyotrophic lateral sclerosis (ALS)-model mice that express an ALS-linked mutated SOD 1 in their muscles (Chen et al., 2015). Here, CALR is linked to amyotrophic lateral sclerosis.