Although GH-excess did not cause any consistent variation in the levels of the low amounts of IGF1 RNA detected, GHRKD resulted in a 2-fold [MDA-MB-435] to 8.6-fold [MALME-3M] increase of IGF1 RNA in the four melanoma cells (Figure 5b1, Supplementary Figure 6a, 7a, 8a). Here, GH1 is linked to melanoma.