While the effect of GH excess in changing protein levels of N-cadherin, vimentin, and E-cadherin was not significant (data not shown), GHRKD caused marked downregulation (∼50%) of N-cadherin (Figure 4 (d, g)) and vimentin (Figure 4 (e, g)) proteins in all melanoma cell lines. This evidence concerns the gene CDH2 and melanoma.