Our observations of reappearance or increase of epithelial markers (E-cadherin) and a marked concomitant downregulation of mesenchymal markers like N-cadherin and vimentin following GHRKD, at both RNA and protein levels thus describe a unique role of GH as an important regulator of EMT and aggressive phenotypes of melanoma multi-drug resistance and metastasis. The gene discussed is CDH1; the disease is melanoma.