STAT1 and melanoma: We additionally found other routes of GH induced signaling downstream of JAK2 and SRC [24–32], including GH-induced increases in phosphorylation states of STAT5 (Figure 3c, Supplementary Figure 3b), STAT1 (Figure 3d, Supplementary Figure 3c), STAT3 (Figure 3e, Supplementary Figure 3d) as well as of AKT (Figure 3g, Supplementary Figure 3f), mTOR (Figure 3h, Supplementary Figure 3g), and ERK1/2 (Figure 3i, Supplementary Figure 3h) in all four human melanoma cell lines.