Thus, our results indicating significant basal activation of JAK2, SRC, STATs 1, 3, and 5, in melanoma aids in resolving finer aspects of STAT1 vs. STAT3 as well as acts as a springboard for dissecting studies on cytokine-induced STAT mediated cross-talks between JAK and SRC pathways [31, 124]. Here, STAT3 is linked to melanoma.