GH1 and melanoma: Lastly, in course of studying two spectrums of GH action – GH excess and GHRKD – on human melanoma cells, we also identified significant modulation with response to changes in GH action in a set of three genes - the autocrine system of hepatocyte growth factor (HGF) and its cognate receptor tyrosine kinase MET, and the Erb-B2 receptor tyrosine kinase 3 (ERBB3 or HER3) - reported to be induced by GH in different tissues [74] as well as known to be critical drivers of aggressive disease progression and melanoma drug resistance [75–80].