IGHE and immunoglobulin G4-related sclerosing disease: We report a frequent clinical history of allergy (63%) and atopy (40%) in IgG4-RD, supported by retrospective data in Japanese patients with AIP,2 but not by other groups.3, 14, 15 Peripheral eosinophilia and elevated IgE have also been described in subsets of IgG4-RD patients without atopy.15