IGHE and immunoglobulin G4-related sclerosing disease: To establish if there was a particular allergen prevalent in IgG4-RD and to investigate whether an IgE-specific response was more prevalent in those with an elevated total IgE, we tested the serum of 16 patients with elevated IgE and 17 patients with normal IgE levels to 4 broad allergen panels (grass, mold, tree, and nut mixes).