Upon mass spectrometry analysis of Parkin oxidation, authors also showed that several of the Parkin cysteine that are sulfonated upon oxidative stress (Cys 212, Cys 253, Cys 268, Cys 289, Cys 431 and Cys 441) were previously reported to be mutated in familial PD cases, supporting the hypothesis that rare hereditary mutations and environmentally linked PD cases might share a common mechanism of inactivation of Parkin. The gene discussed is PRKN; the disease is Parkinson disease.