TNF and rheumatoid arthritis: After start of anti-TNF-α treatment, in combination with preexisting synthetic immunosuppressants, 25/208 (12%, 15 RA and 10 PsA, Group A) showed a significant increase in the lymphocyte count leading to a mild lymphocytosis [from 2800 to 4000 mean cells/μl (mean ratio of increase 1.44); P < 0.001; Fig. 1], whereas in the remaining 183 patients (Group B) lymphocyte count remained substantially stable (from 1866 to 2012 [mean ratio of increase 1.1]) (Table 1).