We identified additional somatic missense DICER1 mutations in CN and ERMS tumors (p.G1809R and p.D1810H, respectively), affecting metal ion-binding regions of the protein and thus presumably affecting catalytic activity of RNAseIIIb (but not RNAaseIIIa) domain [3]. The gene discussed is DICER1; the disease is embryonal rhabdomyosarcoma.