Assessment of cellular proliferation by Ki-67 expression is not recommended in routine pathological evaluation by either International Ki-67 in Breast Cancer Working Group of the Breast International Group and North American Breast Cancer Group or the American Society of Clinical Oncology (ASCO) given the fact that it is not totally clear how Ki-67 measurements and thresholds could influence clinical decisions [7]. The gene discussed is MKI67; the disease is breast carcinoma.