Indeed, high levels of lymphoid chemokines CXCL13 and CXCL12, having a key role in the regulation of B cell migration and compartmentalization within secondary lymphoid organs [9], IL6 and IL10, involved in plasma blast differentiation/class switching as well as B cell regulatory immune activity, and BAFF, APRIL, and osteopontin, involved in the balance between activation, survival and apoptosis of B and T cells [30], were observed in OCB+ MS patients only. The gene discussed is SPP1; the disease is myeloid sarcoma.