The increased expression of several inflammatory molecules such as IFNγ, TNF, IL8, IL10, IL6, MMP2, and osteopontin found in OCB+ MS patients indicate higher levels of intrathecal inflammatory activity that may be directly involved in the cortical tissue damage, as well as indirectly by activation of resident glial cells. This evidence concerns the gene CXCL8 and myeloid sarcoma.