In the OCB+ MS patients, CL load significantly correlated with levels of several molecules linked to the B cell immune response, such as CXCL13 (r = 0.922; p < 0.001), CXCL12 (r = 0.678; p = 0.022), OPN (r = 0.692; p = 0.018), IL6 (r = 0.628; p = 0.039), TWEAK (r = 0.629; p = 0.038) (Fig. 3). Here, SPP1 is linked to myeloid sarcoma.