Our data showed that the main IL-1β response against infection occurs in the TG (Fig. 2b, left and Additional file 1: Figure S1a), as indicated by the high % of cells producing this cytokine in this tissue (with no significant differential detection in the spleen) (Fig. 2c and Additional file 1: Figure S1b) and that myeloid cells derived from TLR2/9−/− mice were unable to produce this cytokine, as shown by the impaired production in the TG observed in mock-infected and infected mice (Fig. 2b, left). Here, IL1B is linked to infection.