Moreover, it was demonstrated that the adaptor molecule MyD88 or the TLR2 and TLR9 receptors together are crucial to host survival, since mice deficient in these molecules succumb to HSV-1 infection with encephalitis, whereas wild-type (WT) C57BL/6 mice can control the infection and survive [8, 9]. The gene discussed is TLR2; the disease is infection.