PNPLA2 and Other metabolic disease: Among the genes that showed both differential gene expression and methylation in only obese, were genes previously associated with dysfunctional myogenesis, e.g., PLCB1 and CDK9 [65, 66], genes linked to obesity or other metabolic diseases, including IL18, PNPLA2, and ENHO [67–69], as well as genes for which an association to obesity has never been described.