Of these variants, three (BRCA2 p.Ile1929Val, p.Lys2729Asn and p.Ile3412Val) have been classified as Class 1 (not pathogenic) and one (BRCA2 p.Arg2108Cys) has been classified as Class 2 (likely not pathogenic) in either Breast Cancer Information Core Database (http://research.nhgri.nih.gov/bic/) or DatabaseARUP Laboratories BRCA Mutation Database (http://arup.utah.edu/database/BRCA/) using different approaches [20, 23]. Here, BRCA2 is linked to breast cancer.