TSC1 and tuberous sclerosis: Because TSC can be a devastating disease, family members of affected individuals areoften eager to know whether they are carriers of TSC mutations.Currently, with the adventure of next generation sequencing platforms, it becamepossible to analyze point mutations in both TSC1 andTSC2 genes at the same time for a lower cost; if no mutations aredetected, the search for large deletions and duplications should proceed.