We previously showed that canine HSA tumor-initiating cells express epidermal growth factor receptors (EGFR) and urokinase plasminogen activator receptors (uPAR), and that these cells are effectively killed by a bispecific EGF-urokinase angiotoxin (eBAT) designed to target EGFR and uPAR simultaneously [24]. This evidence concerns the gene EGFR and neoplasm.