CD4 and hepatitis A virus infection: NVP-related hepatotoxicity occurs almost exclusively during the first 6 weeks of treatment, which is more likely to develop in women with CD4 cell counts >250 cells/μl and in men with CD4 cell counts >400 cells/μl [23, 24], In previous studies, the associated factors with EFV-related hepatotoxicity were hepatitis C virus (HCV) coinfection and excessive alcohol use [25, 26]; moreover, skin rash has been reported to be associated with symptomatic hepatitis [23].