In univariate analysis in NVP group (data not shown), we found that baseline CD4 cell count (P = 0.002), HBsAg positivity (P = 0.04) and development of skin rash within 4 weeks of cART (P<0.001) were associated with hepatotoxicity of grade 2 or greater. The gene discussed is CD4; the disease is Skin rash.