In multiple logistic regression analysis, a higher baseline CD4 cell count (per 100-cell/μl increase, AOR, 1.705; 95% CI, 1.187–2.449) and development of skin rashes (AOR, 4.704; 95% CI, 1.537–14.394) were independently associated with the development of hepatotoxicity. This evidence concerns the gene CD4 and exanthem.