CXCL8 and Alzheimer disease: IL-8, also known as neutrophil chemotactic factor, induces chemotaxis and phagocytosis in target cells, primarily neutrophils, inducing them to migrate toward the site of infection.60 Elevated IL-8 levels have been found in patients with inflammatory-related diseases, such as Alzheimer's disease,61 major depressive disorder62, 63, 64 and cardiovascular diseases.65, 66