Indeed, the highly localized iron accumulation in the GP in CUD patients is reminiscent of the ‘eye of the tiger' sign on T2-weighted magnetic resonance imaging in pantothenate kinase-associated neurodegeneration (formerly Hallervorden-Spatz syndrome); a rare, rapidly progressive neurodegenerative disorder with childhood onset and prominent extrapyramidal symptoms. This evidence concerns the gene PANK1 and pantothenate kinase-associated neurodegeneration.