For the same set of 1392 genes, the most highly significant canonical pathways were “Synaptic Long Term Depression” (P = 1.2e-8), “Axonal Guidance Signaling” (P = 3.4e-7), “CREB (cAMP response element-binding protein) Signaling in Neurons” (P = 4.3e-7), “Neuropathic Pain Signaling in Dorsal Horn Neurons” (P = 4.7e-7), and “Melatonin signalling” (P = 5e-7). The gene discussed is CREB1; the disease is major depressive disorder.