HAO2 and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: Interestingly, 10 peroxisomal proteins were less abundant in the outer medulla of ADTKD-UMOD compared to control kidneys, and only one (HAO2) was more abundant (Fig. 3C, Supplementary Table 6), suggesting impaired biogenesis of peroxisomes.