NRF1 and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: In ADTKD-UMOD affected kidneys, the abundance of the glycosylated 120-kDa NRF1 isoform and – to a lesser extent – of a 65–70-kDa NRF1 isoform was increased, whereas the abundance of the 95-kDa full-length non-/de-glycosylated NRF1 isoform was similar between Umod mutant mice and wild-type mice (Fig. 4A).