The combination of a group of significant risk markers of AML transformation (DNMT3A, TP53, WT1, SRSF2, IDH1/2, STAG2 and ROBO1/2) and the cumulative effects of mutations in 19 other genes predicted three subgroups with significantly different AML transformation rates. The gene discussed is SRSF2; the disease is acute myeloid leukemia.