IDH1/2 (P = 9.9E-06, HR = 13.394), a high IPSS-R score (P = 2.7E-11, HR = 1.729), DNMT3A (P = 1.0E-03, HR = 3.105), TP53 (P = 5.0E-03, HR = 2.966), SRSF2 (P = 8.0E-03, HR = 4.664), WT1 (P = 9.0E-03, HR = 6.128) and STAG2 (P = 3.1E-02, HR = 3.948) were defined as independent AML transformation-associated indicators. The gene discussed is TP53; the disease is acute myeloid leukemia.