We administered enoxaparin (a low molecular weight heparin), fondaparinux (a synthetic, selective FXa inhibitor) or dabigatran (a direct FIIa inhibitor) to angiotensin II (AngII)-infused apolipoprotein E deficient (ApoE−/−) mice to assess the effect of anticoagulation therapy in an experimental model of aortic aneurysm that incorporates thrombus formation and atherosclerosis. The gene discussed is AGT; the disease is aortic aneurysm.