To investigate the role of PTEN in modulating the response to MAPK or PI3K pathway inhibition, panels of thirty tumor cell lines of different histological origin (melanoma, n = 7; breast cancer, n = 6; non-small cell lung cancer, n = 6; colorectal cancer, n = 8; pancreatic adenocarcinoma, n = 2; glioblastoma, n = 1; Table 1) were analyzed for PTEN gene status. This evidence concerns the gene PTEN and colorectal cancer.