PTEN and neoplasm: Interestingly, NFκB and STAT3 extensively cross-regulate each other47 and synergistically control a common set of genes encoding for cytokines and chemokines48, 49, such as IL-8, which may constitute a common target of the anti-tumor activity of combined MEK/mTOR inhibition in PTEN-loss contexts, particularly in vivo, through modulation of tumor/microenvironment interactions.