PTEN and melanoma: Similar results were obtained in ME8959 (PTEN-competent; CI: 1 and 13.7 for MK-2206/Trametinib and PF-05212384/Trametinib combinations, respectively) and C32 (PTEN-loss; CI: 0.5 for both MK-2206/Trametinib and PF-05212384/Trametinib combinations) melanoma cell lines (data not shown).