Clinical trials combining alisertib and targeted therapies such as the epidermal growth factor receptor (EGFR) inhibitor (EGFRi) erlotinib, (NCT01471964), the pan-RAFi MLN0128 (NCT02327169), the mTORi MLN1117 (NCT02551055) and sapanisertib (NCT02719691) are being conducted in solid tumours, thus paving the path for combination studies with MEKi in KRAS-driven tumours. Here, KRAS is linked to neoplasm.