This analysis across different KRAS-driven tumours unveiled a core of eight genes including AREG, DUSP4, DUSP6, FOSL1, LAMB3, LAMC2, PHLDA1 and SPRY4. Notably, LAMB3 has been reported as a synthetic lethal interaction with oncogenic KRAS in colon cancer21, suggesting that other co-identified genes could also display a functional role in mutant KRAS cancer. Here, SPRY4 is linked to cancer.