Concordant with these alterations, the neutrophil/granulocytic MDSC population made up a larger proportion of the total immune infiltrate in PD-L1-deficient tumours (Fig. 2i), and the strong inflammatory response could be causative for the significant increase of gene sets representing stromal remodelling (Fig. 2g; CAMERA FDR<0.05). This evidence concerns the gene CD274 and neoplasm.