In “typical” cases that were triggered by exertion or sexual activity or emotion fluctuation and accompanied by the symptoms of angina, a diagnosis of CC could be established according to the medical history demonstrating the exact onset of headache concurrently with acute myocardial ischemia, abnormality of ECGs performed at rest or under stress, elevating cardiac markers (CPK-MB, myoglobin, and troponin) and coronary angiography illustrating coronary arteries occlusion or stenosis. The gene discussed is MB; the disease is angina pectoris.