Heterozygous and non-synonymous variants in these genes have been associated with a spectrum of cholestatic conditions, including intrahepatic cholestasis of pregnancy (ICP), benign recurrent intrahepatic cholestasis, susceptibility to drug-induced liver injury, and cholelithiasis (cholesterol gallstones (CG) which, specifically for ABCB4 SNPs, can develop into a syndromic condition termed low-phospholipid associated cholelithiasis (LPAC) in Europe [5] and Oriental Cholangiohepatitis in Japan [6]). The gene discussed is ABCB4; the disease is cholelithiasis.