ABCB4 and liver disorder: ABCB4 non-synonymous SNPs have been reported in human patients with liver cancer (encoding variants I490T [12] and S978P [12]) and also in patients diagnosed with inflammatory liver diseases, such as SC (and LPAC; R545C [13, 14]) and Biliary Cirrhosis (BC; D243A [14], K435T [14] and G535D [15]), both of which are considered to predispose to the development of liver cancer [16–22].