Reconstituted RAG-KO mice with WT spleen cells and sensitized with OVA/Alum developed allergic eosinophilic inflammation, showing increased total and eosinophils cell counts in BAL (Figures 5B,C) as well as increased levels of total and specific IgE, when compared to non-reconstituted (RAG−/−) or reconstituted but non-manipulated (Control) groups (Figures 5D,E). This evidence concerns the gene IGHE and inflammation.