Patients with heart failure, hypertrophy and cardiomyopathies manifest sustained hyperactivity of CaMKII (Erickson et al., 2008, 2011; Mollova et al., 2015) promoting VT/VF (Swaminathan et al., 2012; Luczak and Anderson, 2014). The gene discussed is CAMK2G; the disease is heart failure.