CAMK2G and heart failure: The multifunctional and ubiquitous enzyme CaMKII is a well demonstrated sensor of calcium and redox signaling that enhances the INa-L and late ICa,L and plays a key role in the pathogenesis of heart failure and arrhythmias both in humans and in animal disease models (Erickson et al., 2008; Xie et al., 2009; Belardinelli et al., 2015; Hund and Mohler, 2015; Pezhouman et al., 2015; Mustroph et al., 2016).