In functional imaging studies on aging, AD as well as APOE-E4 have shown to be associated with changes in functional brain activation (Smith et al., 2002; Herrmann et al., 2008; Steffener et al., 2009; Grady, 2012; Kahlaoui et al., 2012; Trachtenberg et al., 2012). The gene discussed is APOE; the disease is Alzheimer disease.