APOE and Alzheimer disease: Finally, by combining significant neuroimaging factors and clinical variables such as ADAS-cog scores, CDR-SB scores and APOE genotype, the comprehensive Cox model provided a more sufficient investigation of MCI progression, revealing that MCI individuals with reduced gray matter volume in a temporal lobe-related network (IC_06) based on structural MRI, low glucose metabolism in the posterior DMN (IC_27) based on FDG-PET, positive APOE ε4-status, increased ADAS-cog scores and CDR-SB scores were more likely to convert to AD within 36 months after baseline than others, as shown in Table 2.