MAPT and frontotemporal dementia: In vivo retention of [18F]AV-1451 was also assessed in cases carrying mutations of the MAPT gene: Bevan-Jones et al. [96] described, in a patient with familial frontotemporal dementia due to a MAPT mutation (MAPT 10 + 16C > T), a retention pattern in agreement with the regional pattern of 4R tau pathology observed in the brain of the deceased father, carrier of the same mutation.