Given that Derlin-1 could be activated by HNF1β, and miR-217 modulated glioma cell progression via targeting 3′-UTR of HNF1β, we next sought to investigate whether Derlin-1 and the downstream pathways were involved in miR-217-induced blunting effect on glioma cells. The gene discussed is DERL1; the disease is central nervous system cancer.