(iii) Several researchers reported that HCMV infection induces the secretion of inflammatory cytokines such as interleukin (IL)-1β in serum of renal transplant recipients who developed a primary HCMV infection and IL-18 produced by HCMV-infected gingival fibroblasts [20, 21]. The gene discussed is IL1B; the disease is cytomegalovirus infection.