TTR and acute myeloid leukemia: Along similar lines, the relatedness between leukemic clones at diagnosis and relapse decreased with increasing TTR: targeted resequencing of 122 recurrently mutated genes in paired samples from 22 patients with cytogenetically heterogeneous AML revealed a significantly larger number of retained mutations in patients relapsing after <3 years than in those relapsing after >5 years, while the number of gained or lost lesions behaved in the opposite manner.