BRAF and metastatic melanoma: In 2015 the FDA extended its approval in four opportunities; on March, for the treatment of patients with metastatic squamous NSCLC with progression on or after platinum-based chemotherapy; on September, for the treatment of unresectable or metastatic melanoma in combination with ipilimumab in BRAF V600 wild-type patients; on October, for the treatment of patients with metastatic NSCLC with progression on or after platinum-based chemotherapy and on November, for the treatment of advanced renal cell carcinoma in patients who have received prior anti-angiogenic therapy.