IL2 and neuroblastoma: UnituxinTM underwent priority review by the FDA and received approval with an orphan drug designation in 2015 to be used in combination with granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-2 (IL-2) and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy [55, 57].