BIRC5 and breast cancer: FBXL7 has been shown to induce the ubiquitylation of AURKA during mitosis50 and Survivin in a cell cycle-independent manner.48 FBXL7 is a potential tumor suppressor gene as a previous study found an association between SNPs in FBXL7 and an increased breast cancer risk.51 We showed that in unsynchronized cells, FBXL7 promoted Survivin degradation by proteasomal pathway in our experimental setting, which was in agreement with a previous report,48 while AURKA expression remained unaffected in response to FBXL7 overexpression.