AURKA and gastric cancer: Consistent with this notion, overexpression of AURKA in gastric cells could overcome DNA damage-induced apoptotic cell death (Figure 1d), which again was in agreement with another previous study.32 Recent reports showed that AURKA overexpression was essential for the tumorigenic capacity and drug resistance of breast tumor initiating cells34 as well as chemoresistance in lung cancer cells,40 supporting our study that deregulated overexpression of AURKA in gastric cancer led to clinical chemoresistance.