Previous studies have shown that Survivin is upregulated because of its cytoprotective function in response to several anti-cancer agents, including doxorubicin, suggesting that tumor cells enhance Survivin expression to counteract the apoptotic signals induced by chemotherapeutic agents.42, 54 In our work, we found that doxorubicin alone induced Survivin expression, while the combination of VX-680 and doxorubicin induced apoptotic cell death synergistically in the human gastric BGC823 cells, accompanied by a decrease in AURKA activation and Survivin expression (Figure 3b). This evidence concerns the gene BIRC5 and cancer.