Another group reported that the development of AD is associated with the overexpression of the Th2 and Th22 cytokines, whereas chronic inflammatory responses are mediated by a IFN-γ and IL-12-producing Th1 component and characterized by increased numbers of IgE-bearing cells in the epidermis and the domination of macrophages in the dermal mononuclear cell infiltration [26]. This evidence concerns the gene IGHE and Alzheimer disease.