In HCC, TILs interact with a number of tumor-associated antigens (TAAs), such as glypican-3 (GPC3), α-fetoprotein (AFP), telomerase reverse transcriptase (TERT), synovial sarcoma X breakpoint 2 (SSX-2), melanoma antigen gene-A (MAGE-A), and New York esophageal squamous cell carcinoma 1 (NY-ESO-1) [51]. This evidence concerns the gene AFP and hepatocellular carcinoma.