Interestingly, in contrast to the up-regulated proteins involved in development of fibrosis and stellate cell activation, expression of intermediate filament members cytokeratin 8 (CK8 (KRT8)) and cytokeratin 18 (CK18 (KRT18)) was significantly lower in all examined NASH-associated biopsies and HCCs, while in the majority of examined HCV+ HCCs (70%), we found significant increase in comparison to the normal-appearing liver tissue of patients with gastrointestinal tumor metastases. The gene discussed is KRT18; the disease is digestive system neoplasm.