SMAD7 and metabolic dysfunction-associated steatohepatitis: In NASH-associated biopsies, IPA predicted significant activation of translation regulators IGF2BP1, TGFB1, SMAD3 and significant inhibition of PPARγ (PPARG), α-catenin, SMAD7 and hepatocyte nuclear factor 4A (HNF4A), as in NASH HCCs.