Transcriptional factors prohibitin 1 (PHB1) and prohibitin 2 (PHB2), involved in control of mitochondrial respiration, function, cell proliferation and apoptosis, and related to induced oxidative stress conditions, were strongly overexpressed in NASH HCCs and moderately elevated in HCV+ HCCs, as compared to the normal liver tissue of metastatic tumor patients. Here, PHB1 is linked to metabolic dysfunction-associated steatohepatitis.