The SLC30A3 gene was identified in 1996 and raised major interest, as the corresponding protein was shown to transport Zn into pre-synaptic vesicles of glutamatergic neurones of the cerebral cortex and hippocampus, key regions for the memory formation and with a role in the development of amyloid β plaques in AD [52,53]. The gene discussed is SLC30A3; the disease is Alzheimer disease.