Another study that tested the antitumor activity of UA62784 and 80 analogs against pancreatic cancer cell lines revealed that these compounds potently inhibit several protein kinases that are overexpressed in these cancer cells, but not mitotic Kinesins (Kinesin-5, CENP-E, MKLP-1, and MCAK) [463]. This evidence concerns the gene CENPE and familial pancreatic carcinoma.