Comparison of mutation carriers and non-carriers regarding anthropometric (BMI SD score, height SD score, weight SD score) and biochemical (fasting blood glucose, lipids, insulin, free thyroxine, thyroid-stimulating hormone, adrenocorticotropic hormone, and cortisol) variables revealed no statistically significant differences except for age at onset of obesity (Table 1). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.