2012). Low Pitx2 mRNA also improved the effectiveness of sodium channel blockers in a prospective experimental study (Syeda et al. 2016). PITX2 levels vary in AF patients (Syeda et al. 2016) and given the observation that loss of left atrial Pitx2 facilitates AF, it may be desirable to target those AF patients who have low PITX2 as a distinct population for therapy. There is, however, no clear relation between atrial tissue PITX2 mRNA levels and SNP haplotype of the common gene variants associated with AF in patients (Gore‐Panter et al. 2014, 2016; Syeda et al. 2016). Here, PITX2 is linked to atrial fibrillation.