PITX2 and atrial fibrillation: 2015), but beyond this finding, there is little information on how variants distal to PITX2 interact with PITX2 to cause AF. Interestingly, an AF‐associated SNP proximal to PITX2 has been shown to regulate PITX2c expression in human stem cell‐derived cardiomyocytes by regulating PITX2 enhancer activity (Ye et al. 2016).