SERPINE1 and coronary artery disorder: Thus, PAI-1 mediateshypercoagulable states and thrombosis and studies have suggested that the release ofPAI-1 in response to stress and elevated levels of PAI-1 are associated with thedevelopment of coronary artery disease [30].In inflammatory conditions where fibrin is deposited in tissues, PAI-1 appears toplay a significant role in the progression to fibrosis during inflammatory event.Downregulation of SERPINE1/PAI-1may suggest the inhibition of inflammatorycondition-associated fibrosis.