KLK4 and systemic inflammatory response syndrome: Perioperativeinflammatory responses and/or systemic inflammatory response syndrome (SIRS) withactivation of the coagulation, complement, kallikrein, and fibrinolytic cascades maycontribute significantly to perioperative morbidities and mortalities [11, 12].We hypothesize that epinephrine exposure in cardiomyocytes may alter geneexpressions related to inflammation, which subsequently leads to potential adverseclinical outcomes.